paliperidone Get Now Mechanism of Action Paliperidone works by influencing various neurotransmitter systems in the brain, particularly dopamine and serotonin receptors. It acts as an antagonist at dopamine D2 receptors and serotonin 5-HT2A receptors, helping to rebalance neurotransmitter activity. This modulation helps alleviate symptoms of psychosis, including hallucinations and delusions. [...]