amitriptyline / perphenazine Get Now Classification and Mechanism Amitriptyline is a tricyclic antidepressant (TCA) that primarily affects neurotransmitters in the brain, particularly serotonin and norepinephrine. By inhibiting their reuptake, amitriptyline helps to elevate mood and alleviate symptoms of depression. Uses Depression: Amitriptyline is primarily prescribed for major depressive disorder. Chronic [...]